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大腸・小腸英論文

  1. Kijima T, Hazama S, Tsunedomi R, Okuno K, et al: MicroRNA-6826 and -6875 in plasma are valuable non-invasive biomarkers that predict the efficacy of vaccine treatment against metastatic colorectal cancer. Oncol. Rep. 2016 Nov 22 [Epub ahead of print]
  2. Okuno K, Sugiura F, Inoue K, Sukegawa Y: Clinical trial of a 7-peptide cocktail vaccine with oral chemotherapy for patients with metastatic colorectal cancer. Anticancer Research 34:3045-3052, 2014.
  3. Galon J, Mlecnik B, Bindea G, Okuno K, et al.: Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol 232:199-209, 2014.
  4. Yamaguchi Y, Yamaue H, Okusaka T, Okuno K, et al.: Guidance for peptide vaccines for the treatment of cancer. Cancer Sci 105:924-931, 2014.
  5. Ueno H, Shirouzu K, Shimazaki H, Okuno K, et al.: Histogenesis and prognostic value of myenteric spread in colorectal cancer: a Japanese multi-institutional study. J Gastroenterol 49:400-407, 2014.
  6. Ohtake J, Ohkuri T, Togashi Y, Kitamura H, Okuno K, Nishimura T: Identification of novel helper epitope peptides of Survivin cancer-associated antigen applicable to developing helper/killer-hybrid epitope long peptide cancer vaccine. Immunol Lett 161:20-30, 2014.
  7. Hazama S, Nakamura Y, Hiroaki T, Okuno K, et al.: A phase II study of five peptides combination with oxaliplation-based chemotherapy as a first-line therapy for advanced colorectal cancer (FXV study). J Transl Med 12:108-117, 2014.
  8. Uno K, Okuno K, Hamuro J: Intracellular glutathione in monocytes are useful biomarker of immune status of tumor bearing patients. Eur J Clin Med Oncol 4:21-26, 2012.
  9. Galon J, Franck P, Marincola FM, Okuno K: Cancer classification using the immunoscore: a worldwide task force. J Transl Med 2012 Oct 3; 10: 205.doi: 10.1186/1479-5876-10-205
  10. Okuno K, Sugiura F, Itoh K, Yoshida K, Tsunoda T, Nakamura Y. Recent advances in active specific cancer vaccine treatment for colorectal cancer. Curr Pharm Biotechnol 2012;13:1439-1445.
  11. Okuno K, Horiuchi T, Ishibashi T, Shigeoka H, Hayashibe A, Tsubakihara H. Prognostic factors in gastrointestinal perforation. Hepato-Gastroenterol 2011; 58:1598-1602.
  12. Okuno K, Uno K: Efficacy of orally administered Lentinula edodes Mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study. Asian Pacific Journal of Cancer Prevention 12:1-4, 2011
  13. Okuno K, Sugiura F, Hida J, Tokoro T, Ishimaru E, Sukegawa Y, Ueda K. Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer. Experimental and Therapeutic Medicine 2011;2(1):73-79.
  14. Okuno K. Surgical treatment for digestive cancer. current issues-colon cancer. Dig Surg 2007;24:108-114.
  15. Okuno K, Kawai I, Hirai N, Narimatsu H, Yasutomi M. Role of sialyl Lewis X (SLX) in liver metastasis in view of liver-associated immunity. Hepato-Gastroenterol 2003;50:756-760.
  16. Okuno K, Yasutomi M, Nishimura N, Arakawa T, Shiomi M, Hida J, Ueda K, Minami K. Gene expression analysis in colorectal cancer using practical DNA array filter. Dis Colon Rectum 2001;44:295-299.
  17. Okuno K, Shigeoka H, Tanaka A, Hirai N, Matsumura E, Yasutomi M. Clinicopathologic examination of t2-gastric cancer among age groups. Hepato-Gastroenterol 2000;47:1180-1182.
  18. Okuno K, Hirai N, Takemoto Y, Kawai I, Yasutomi M. Interleukin-2 as a modulator of 5-FU in hepatic arterial immuno-chemotherapy for liver metastases. Hepato-Gastroenterol 2000;47:487-491.
  19. Okuno K, Kaneda K, Yasutomi M. Regional IL-2-based immunochemo-therapy of colorectal liver metastases. Hepato-Gastroenterol 1999;46:1263-1267.
  20. Okuno K, Tanaka A, Shigeoka H, Hirai N, Kawai I, Kitano Y, Yasutomi M. Suppression of T-cell function in gastric cancer patients after total gastrectomy with splenectomy. Gastric Cancer 1999;2:20-25.
  21. Okuno K, Yasutomi M, Kon M, Hatakeyama K, Muto T, Kitajima M, Koyanagi Y, Hamano K, Ohta H, Aiba, K Arai Y, Sowa M, Kikkawa N, Isomoto H. Intrahepatic interleukin-2 with chemotherapy for unresectable liver metastases: a randomized multicenter trial. Hepato-Gastroenterol 1999;46:1116-1121.
  22. Okuno K, Yasutomi M, Hida J, Kayama H, Nakai T, Funai S, Koh K. Longterm effects of hepatic arterial interleukin-2-based immunochemo-therapy after potentially curative resection of colorectal liver metastases. J Am Coll Surg 1998;187:271-275.
  23. Okuno K, Hirai N, Lee YS, Tarabar D, Ueno H, Yasutomi M. Superiority of hepatic arterial infusion in preventing catabolism of 5-FU compared with portal vein infusion revealed by an in vivo 19F NMR study. Cancer Chemother Pharmacol 1998;42:341-344.
  24. Okuno K, Tanaka A, Yoshikawa H, Shigeoka H, Jinnai H, Lee YS, Hirai N, Matsumura E, Kawai I, Yasutomi M. A new preoperative immuno-chemotherapy for the treatment of locally advanced esophageal cancer. Hepato-Gastroenterol 1998;45:950-953.
  25. Okuno K, Hirai N, Lee YS, Kawai I, Shigeoka H, Yasutomi M. Invovement of liver-associated immunity in hepatic metastasis formation. J Surg Res 1998;75:148-152.
  26. Okuno K, Nakamura K, Tanaka A, Yachi K, Yasutomi M. Hepatic immunopotentiation by galactose-entrapped liposomal IL-2 compound in the treatment of liver metastases. Surg Today 1998;28:64-69.
  27. Okuno K, Jinnai H, Lee YS, Kaneda K, Yasutomi M. Interleukin 12 augments the liver-associated immunity and reduces liver metastases. Hepato-Gastroenterol 1996;43:1196-1202.
  28. Okuno K, Shigeoka H, Lee YS, Son E, Kayama H, Nakai T, Koh K, Yasutomi M. Adjuvant hepatic arterial IL-2 and MMC, 5-FU after curative resection of colorectal liver metastases. Hepato-Gastroenterol 1996;43:688-691.
  29. Okuno K, Tanaka A, Shigeoka H, Nakamura K, Jinnai H, Lee YS, Yasutomi M. Immunological assessment of the spleen in patients with gastric cancer. Asian J Surg 1996;19:225-231.
  30. Okuno K, Kobayashi S, Jinnai H, Lee Y, Yasutomi M. IL-2 perfusion to the liver augments the hepatic extraction rate of accompanying anti-cancer drugs. Surg Today 1996;26:662-664.
  31. Okuno K, Jinnai H, Lee YS, Nakamura K, Hirohata T, Shigeoka H, Shindo K, Yasutomi M. High prostaglandin E2 (PGE2) level in portal vein suppresses the liver-associated immunity and promotes liver metastasis. Surg Today 1995;25:954-958.
  32. Okuno K, Ozaki M, Shigeoka H, Jinnai H, Hirohata T, Yasutomi M. Effect of packed red cell and whole blood transfusion on liver-associated immune function. Am J Surg 1994;168:340-344.
  33. Okuno K, Ohnishi H, Nakajima I, Akabane Y, Kurooka K, Koh K, Shindo K, Yasutomi M. Complete remission of liver metastases from colorectal cancer by treatment with a hepatic artery infusion of interleukin-2-based immunochemotherapy: reports of three cases. Surg Today 1994;24: 80-84.
  34. Okuno K, Hirohata T, Nakamura K, Jinnai H, Shigeoka H, Koh K, Shindo H, Yasutomi M. Hepatic arterial infusion of interleukin-2-based immunochemo-therapy in the treatment of unresectable liver metastases from colorectal cancer. Clin Ther 1993;15:672-683.
  35. Okuno K, Ohnishi H, Shilayama Y, Hirohata T, Ozaki M, Yasutomi M. Augmentation of human lymphokine-activated killer cell activity in splenic lymphocytes by the combination of low-dose IL-2 plus IL-3. Molecular Biotherapy 1992;4:83-86.
  36. Okuno K, Ohnishi H, Koh K, Shindo H, Yoshioka H, Yasutomi M. Clinical trials of intrasplenic arterial infusion of interleukin-2 (IS-IL-2) to patients with advanced cancer. Biotherapy 1992;4:257-265.
  37. Okuno K, Takagi H, Nakamura T, Nakamura Y, Iwasa Z, Yasutomi M. Treatment for unresectable hepatoma via selective hepatic arterial infusion of lymphokine-activated killer cells generated from autologous spleen cells. Cancer 1986;58:1001-1006.
  38. Okuno K, Kikuchi Y, Tsuchida T, Hamaoka T, Igarashi T, Kato R, Takatsu K. The role of I-region assocciated antigen (Ia)-bearing accessory cells in the generation of cytotoxic T cells in a subpopulation of thymocytes. Jpn J Cancer Res (Gann) 1986;77:711-721.
  39. Okuno K, Hashimoto T, Qian JH, Tsuchida T, Fujiwara H, Hamaoka T. Prevention of tumor metastasis after surgical removal of primary tumor by using in vitro activated macrophages. Jpn J Clin Oncol 1985;15:87-94.
  40. Okuno K, Takatsu K, Takahama Y, Kitamura Y, Hamaoka T. Interleukin-1 restores the impaired cytotoxic T lymphocyte generation in beige mutant mice. Jpn J Cancer Res (Gann) 1984;75:824-830.
  41. Ogawa S, Hida J, Ike H, Kinugasa T, Ota M, Shinto E, Itabashi M, Okamoto T, Sugihara K. The important risk factor for lateral pelvic lymph node metastasis of lower rectal cancer is node-positive status on magnetic resonance imaging: study of the Lymph Node Committee of Japanese Society for Cancer of the Colon and Rectum. Int J Colorectal Dis 31(10):1719-1728, 2016.
  42. Ogawa S, Hida J, Ike H, Kinugasa T, Ota M, Shinto E, Itabashi M, Kameoka S, Sugihara K. Selection of lymph node-positive cases based on perirectal and lateral pelvic lymph nodes using magnetic resonance imaging: study of the Japanese Society for Cancer of the Colon and Rectum. Ann Surg Oncol, 23(4):1187-1194, 2016.
  43. Hida J, Okuno K, Tokoro T: Distal dissection in total mesorectal excision, and preoperative chemoradiotherapy and lateral lymph node dissection for rectal cancer. Surg Today 44(12):2227-2242, 2014.
  44. Hida J, Okuno K: High ligation of the inferior mesenteric artery in rectal cancer surgery. Surg Today 43:8-19, 2013.
  45. Kobayashi H, Mochizuki H, Kato T, Mori T, Kameoka S, Shirouzu K, Saito Y, Watanabe M, Morita T, Hida J, Ueno M, Ono M, Yasuno M, Sugihara K. Lymph node ratio is a powerful prognostic index in patients with stage III distal rectal cancer; a Japanese multicenter study. Int J Colorectal Dis 26:891-896, 2011.
  46. Hida J, Okuno K. Pouch operation for rectal cancer. Surg Today (Review Article) 2010;40(4):307-314.
  47. Kobayashi H, Mochizuki H, Kato T, Mori T, Kameoka S, Shirouzu K, Saito Y, Watanabe M, Morita T, Hida J, Ueno M, Ono M, Yasuno M, Sugihara K. Is total mesorectal excision always necessary for T1-T2 lower rectal cancer? Ann Surg Oncol 17(4):973-980, 2010.
  48. Hida J, Yoshifuji T, Matsuzaki T, Hattori T, Ueda K, Ishimaru E, Tokoro T, Yasutomi M, Shiozaki H, Okuno K. Long-term functional changes after low anterior resection for rectal cancer compared between a colonic J-pouch and a straight anastomosis. Hepato-Gastroenterol 2007;54(74):407-413.
  49. Hida J, Yoshifuji T, Okuno K, Matsuzaki T, Uchida T, Ishimaru E, Tokoro T, Yasutomi M, Shiozaki H. Long-term functional outcome of colonic J-pouch reconstruction after low anterior resection for rectal cancer. Surg Today 2006;36(5):441-449.
  50. Hida J, Okuno K, Yasutomi M, Yoshifuji T, Matsuzaki T, Uchida T, Ishimaru E, Tokoro T, Shiozaki H. Number versus distribution in classifying in regional lymph node metastases from colon cancer. J Am Coll Surg 2005;201(2):217-222.
  51. Hida J, Okuno K, Yasutomi M, Yoshifuji T, Uchida T, Tokoro T, Shiozaki H. Optimal ligation level of the primary feeding artery and bowel resection in colon cancer surgery: the influence of the site of the primary feeding artery. Dis Colon Rectum 2005;48(12):2232-2237.
  52. Hida J, Yoshifuji T, Tokoro T, Inoue K, Matsuzaki T, Okuno K, Shiozaki H, Yasutomi M. Long-term functional outcome of low anterior resection with colonic J-pouch reconstruction for rectal cancer in the elderly. Dis Colon Rectum 2004;47(9):1448-1454.
  53. Hida J, Yoshifuji T, Tokoro T, Inoue K, Mtsuzaki T, Okuno K, Shiozaki H, Yasutomi M. Comparison of long-term functional results of colonic J-pouch and straight anastomosis after low anterior resection for rectal cancer: a five-year follow-up. Dis Colon Rectum 2004;47(10):1578-1585.
  54. Hida J, Yasutomi M, Maruyama T, Nakajima A, Uchida T, Wakano T, Tokoro T, Kubo R, Umemura H, Shindo K. Coloanal anastomosis using a circular stapling device following perineal rectosigmoidectomy for rectal prolapse. Surg Today 1999;29:93-94.
  55. Hida J, Yasutomi M, Maruyama T, Uchida T, Nakajima A, Wakano T, Tokoro T, Kubo R. High ligation of the inferior mesenteric artery with hypogastric nerve preservation in rectal cancer surgery. Surg Today 1999;29:482-483.
  56. Hida J, Yasutomi M, Tokoro T, Kubo R. Examination of nodal metastases by a clearing method supports pelvic plexus preservation in rectal cancer surgery. Dis Colon Rectum 1999;42:510-514.
  57. Hida J, Yasutomi M, Maruyama T, Uchida T, Wakano T, Tokoro T. Technique of pelvic lymph node dissection with preservation of the pelvic autonomic nerve plexus in rectal cancer surgery. Journal of Pelvic Surgery 1999;5:221-223.
  58. Hida J, Yasutomi M, Maruyama T, Tokoro T, Wakano T, Uchida T. Enlargement of colonic pouch after proctectomy and coloanal anastomosis: potential cause for evacuation difficulty. Dis Colon Rectum 1999;42:1181-1188.
  59. Hida J, Yasutomi M, Maruyama T, Tokoro T, Uchida T, Wakano T, Kubo R. Horizontal inclination of the longitudinal axis of the colonic J-pouch: defining causes of evacuation difficulty. Dis Colon Rectum 1999;42:1560-1568.
  60. Hida J, Yasutomi M, Maruyama T, Yoshifuji T, Tokoro T, Wakano T, Uchida T, Ueda K. Detection of a rectocele-like prolapse in the colonic J-pouch using pouchography: cause or effect of evacuation difficulties? Surg Today 1999;29:1237-1242.
  61. Hida J, Yasutomi M, Maruyama T, Nakajima A, Uchida T, Wakano T, Tokoro T, Fujimoto K. Results from pelvic exenteration for locally advanced colorectal cancer with lymph node metastases. Dis Colon Rectum 1998;41:165-168.
  62. Hida J, Yasutomi M, Maruyama T, Fujimoto K, Nakajima A, Uchida T, Wakano T, Tokoro T, Kubo R, Shindo K. Indications for colonic J-pouch reconstruction after anterior resection for rectal cancer: determining the optimum level of anastomosis. Dis Colon Rectum 1998;41:558-563.
  63. Hida J, Yasutomi M, Maruyama T, Tokoro T, Uchida T, Nakajima A, Wakano T, Kubo R, Shindo K. Quality of life in patients treated with abdominoperineal resection for rectal cancer. Journal of Pelvic Surgery 1998;4:265-270.
  64. Hida J, Yasutomi M, Maruyama T, Fujimoto K, Nakajima A, Uchida T, Wakano T, Tokoro T, Kubo R, Shindo K. Indication for using high ligation of the inferior mesenteric artery in rectal cancer surgery: examination of nodal metastases by the clearing method. Dis Colon Rectum 1998;41:984-991.
  65. Hida J, Yasutomi M, Maruyama T, Wakano T, Uchida T, Fujimoto K, Kubo R, Inufusa H, Umemura H, Shindo K. Anterior resection following posterior transsacral stapling and transection of the anal canal for low-lying rectal cancer in males. Surg Today 1998;28:768-769.
  66. Hida J, Yasutomi M, Maruyama T, Fujimoto K, Uchida T, Okuno K. Lymph node metastases detected in the mesorectum distal to carcinoma of the rectum by the clearing method: Justification of total mesorectal excision. J Am Coll Surg 1997;184:584-588.
  67. Hida J, Yasutomi M, Fujimoto K, MaruyamaT, Okuno K, Shindo K. Does lateral lymph node dissection improve survival in rectal carcinoma?: examination of node metastases by the clearing method. J Am Coll Surg 1997;184:475- 480.
  68. Hida J, Yasutomi M, Fujimoto K, Maruyama T, Uchida T, Koh K, Okuno K, Shindo K. Functional outcome after low anterior resection for rectal cancer using the colonic J-pouch. Surg Today 1997;27:1109-1112.
  69. Hida J, Yasutomi M, Maruyama T, Fujimoto K, Uchida T, Okuno K. The extent of lymph node dissecton for colon carcinoma: the potential impact on laparoscopic sugery. Cancer 1997;80:188-192.
  70. Hida J, Yasutomi M, Shindo K, Kitaoka M, Fujimoto K, Ieda S, Machidera N, Kubo R, Morikawa E, Inufusa H, Watatani M, Okuno K. Second-look operation for recurrent colorectal cancer based on carcinoembryonic antigen and imaging techniques. Dis Colon Rectum 1996;39:74-79.
  71. Hida J, Yasutomi M, Maruyama T, Fujimoto K, Uchida T, Okuno K. Comparison between the Japanese general rules and the TNM system in the regional lymph node classification of carcinoma of the colon. J Am Coll Surg 1996;183:611-615.
  72. Hida J, Yasutomi M, Fujimoto K, Ieda S, Machidera N, Kubo R, Shindo K. Analysis of regional lymph node metastases from rectal carcinoma by the clearing method: justification of the use of sigmoid colon in J-pouch construction after low anterior resection. Dis Colon Rectum 1996;39:1282-1285.
  73. Hida J, Yasutomi M, Fujimoto K, Okuno K, Ieda S, Machidera N, Kubo R, Shindo K, Koh K. Functional outcome after low anterior resection with low anastomosis for rectal cancer using the colonic J-pouch: prospective randomized study for determination of optimum pouch size. Dis Colon Rectum 1996;39:986-991.
  74. Hida J, Matsuda T, Kitaoka M, Machidera N, Kubo R, Yasutomi M. The role of basement membrane in colorectal cancer invasion and metastasis. Cancer 1994;74:592-598.
  75. Hida J, Mori N, Kubo R, Matsuda T, Morikawa E, Kitaoka M, Shindo K, Yasutomi M. Metastases from carcinoma of the colon and rectum detected in small lymph nodes by the clearing method. J Am Coll Surg 1994;178:223-228.
  76. Tokoro T, Okuno K, Hida J, Ueda K, Yoshifuji T, Daito K, Sugiura F: Prognostic factors for patients with advanced colorectal cancer and symptomatic brain metastases. Clinical Colorectal Cancer 13(4):226-231, 2014.
  77. Tokoro T, Okuno K, Hida J, Ueda K, Yoshifuji T, Daito K, Takemoto M, Sugiura F: Clinical factors associated with anal function after intersphincteric resection for very low rectal cancer. World Journal of Surgical Oncology 2013, 11:24, doi:10.1186/1477-7819-11-24, 201
  78. Tokoro T, Okuno K, Hida J, Ishimaru E, Ueda K, Yoshifuji T. Depth of mesorectal invasion has prognostic significance in T3N0 low rectal cancer. Hepato-Gastroenterol 2009;56(1):124-127.
  79. Tokoro T, Okuno, Hida J, Ishimaru E, Yoshifuji T, Matsuzaki T, Yasutomi M, Shiozaki H. Anal canal basaloid carcinoma showing histological variants: report of a case and review of the Japanese literature. Acta Med Kinki Univ 2006;31(1):39-43.
  80. Tokoro T, Yasutomi M, Shindo K, Inufusa H, Kubo R, Hida J, Maruyama T, Wakano T, Uchida T. Prognosis of rectal cancer in pTNM classification. Annals of Cancer Research and Therapy 1998;7(1):53-54.
  81. Tokoro T, Ito H, Suzuki T. Alterations in mitochondrial DNA and enzyme activities in hypertrophied myocardium of stroke-prone SHR. Clinical and Experimental Hypertension 1996;18(5):595-606.
  82. Tokoro T. Pathophysiological characteristics of mitochondria and structural abnormality of mitochondrial DNA in hypertrophied myocardium of stroke-prone SHR. Acta Med Kinki Univ 1995;20(3):169-179.
  83. Tokoro T, Ito H, Suzuki T. Mitochondrial abnormalities in hypertrophied myocardium of stroke-prone SHR. Clinical and Experimental Pharmacology and Physiology 1994;22:s268-s269.
  84. Ishimaru E, Kubota A, Yonekura T, Sakakura S, Noguchi J, Ueda S, Oyanagi H, Kitayama Y, Imura K. Congenital esophageal atresia with tracheoesophageal fistula occurring in both members of dizygotic twins. Pediatr Surg Int 1998;13:88-90.
  85. Sugiura F, Okuno K, Inoue K, Hida J. Clinical responses of colorectal cancer-specific peptide vaccination in combination with tegafur-uracil and leucovorin for advanced colorectal cancer patients. (Ed.) Bruno Cola, XXV Biennial Congress of the International Society of University Colon and Rectal Surgeons (ISUCRS)-X National Congress of Italian Society of University Surgeons (SICU), Medimond S. r. l., Bologna, Italy, p. 163-166, 2012年6月
  86. Yoshioka Y, Togashi Y, Chikugo T, Kogita A, Taguri M, Terashima M, Mizukami T, Hayashi H, Sakai K, de Velasco M, Tomida S, Fujita Y, Tokoro T, Ito A, Okuno K, Nishio K. Clinicopathological and genetic differences between low-grade and high-grade colorectal mucinous adenocarcinoma. Cancer, 121(24):4359-4368, 2015.
  87. Imano M, Okuno K, Itoh T, Ishimaru E, Satou T, Shiozaki H. Increased osteopontin-positive macrophage expression in colorectal cancer stroma with synchronous liver metastasis. World J Surg 34(8):1930-1936, 2010.

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